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Emavusertib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Emavusertib图片
CAS NO:1801344-14-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Emavusertib (CA-4948) 是一种有效的 IRAK4/FLT3 抑制剂,具有抗肿瘤活性。
Cas No.1801344-14-8
别名CA-4948
Canonical SMILESO=C(C1=COC(C2=CC=NC(C)=C2)=N1)NC3=C(N4CC[C@@H](O)C4)N=C5C(OC(N6CCOCC6)=N5)=C3
分子式C24H25N7O5
分子量491.5
溶解度DMSO: soluble
储存条件-20буC
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Emavusertib is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4; IC50= 31.7 nM).1It is selective for IRAK4 over FMS-related tyrosine kinase 3 (FLT3), cyclin-dependent kinase 2 (Cdk2), Aurora A kinase, glycogen synthase kinase 3β (GSK3β), and muscle-associated receptor tyrosine kinase (MUSK) at 1 µM. Emavusertib inhibits IL-6 release mediated by toll-like receptor 2 (TLR2), TLR5, or IL-1 receptor (IL-1R) in isolated human whole blood (IC50s = 989, 696, and 1,375 nM, respectively).In vivo, emavusertib (25-200 mg/kg) reduces tumor volume in an OCI-Ly3 diffuse large B cell lymphoma (DLBCL) mouse xenograft model.

1.Gummadi, V.R., Boruah, A., Ainan, B.R., et al.Discovery of CA-4948, an orally bioavailable IRAK4 inhibitor for treatment of hematologic malignanciesACS Med. Chem. Lett.11(12)2374-2381(2020)