CAS NO: | 1416334-69-4 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
Cas No. | 1416334-69-4 |
Canonical SMILES | O=S(NC1=C(F)C=CC=C1)(C2=C(OC)N=CC(C3=CC4=C(N=C(N4C5=CC=C(N6CCOCC6)C=C5)N)C=C3)=C2)=O |
分子式 | C29H27FN6O4S |
分子量 | 574.6 |
溶解度 | DMSO: 2 mg/ml |
储存条件 | Store at -20° |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
文献引用 | |
产品描述 | GSK-A1 is an inhibitor of phosphatidylinositol 4-kinase IIIα (PI4KIIIα; IC50= 3.16 nM).1It is selective for PI4KIIIα over PI4KIIIβ, PI3Kα, PI3Kβ, and PI3Kδ (IC50s = >50 nM) but also inhibits PI3Kγ (IC50= 15.8 nM). GSK-A1 decreases the levels of phosphatidylinositol 4-phosphate (PtdIns-(4)-P1) but not PtdIns-(4,5)-P2in HEK293 cells expressing the angiotensin II type 1 (AT1) receptor (IC50= 3 nM). GSK-A1 inhibits hepatitis C virus (HCV) genotype 1a and 1b replication. 1.Bojjireddy, N., Botyanszki, J., Hammond, G., et al.Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levelsJ. Biol. Chem.289(9)6120-6132(2014) |