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Levetiracetam
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Levetiracetam图片
CAS NO:102767-28-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
100mg电议

产品介绍
左乙拉西坦是一种抗癫痫药,与突触小泡蛋白 SV2A 结合。
Cas No.102767-28-2
别名左乙拉西坦; UCB L059
化学名(2S)-2-(2-oxopyrrolidin-1-yl)butanamide
Canonical SMILESCCC(C(=O)N)N1CCCC1=O
分子式C8H14N2O2
分子量170.21
溶解度DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 16.7 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Levetiracetam (LEV) is a newly developed antiepileptic drug (AED) with a broad spectrum of efficacy against partial and generalized seizures. [1]

The mode of action of LEV seems to be different from other AED. Synaptic vesicle protein 2A which can block calcium release from intraneuronal stores is shown to be the binding site of levetiracetam. Thus, it works against the negative modulators of gamma-aminobutyric acid and glycin-gated currents. Moreover, LEV does not have the ablility to induce cytochrome P450 isoenzyme.[2]

A study has shown that an oral dose of LEV can’t bind to plasma proteins, while no hepatic metabolism was observed. One-third of the metabolized drug was found to be hydrolyzed and the others were excreted unchanged in the urine.[3]

References:
[1] Nabil J. Azar, Patsy Aune. Acute pancreatitis and elevated liver transaminases after rapid titration of oral levetiracetam. Journal of Clinical Neuroscience. June 2014. 21(6): 1053-1054.
[2] Xiao-Qiao Chen, Wei-Na Zhang, Zhi-Xian Yang, Meng Zhao, Fang-Cheng Cai, Shao-Ping Huang, Li Gao, Bao-Dong Pang, Xi Chen, Li-Ping Zou. Efficacy of Levetiracetam in Electrical Status Epilepticus During Sleep of Children: A Multicenter Experience. Pediatric Neurology. March 2014. 50(3): 243-249.
[3] Shahnaz Akhtar Chaudhry, Geert’t Jong, Gideon Koren. The fetal safety of Levetiracetam: A systematic review. Reproductive Toxicology. July 2014. 46: 40-45.