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signal transducer and activator of transcription 6 fragment
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
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包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍

STAT6 transcription factor

别名H2N-Ser-Tyr-Trp-Ser-Asp-Arg-Leu-Ile-Ile-OH
Canonical SMILESOCC(N)C(NC(CC1=CC=C(O)C=C1)C(NC(CC2=CNC3=C2C=CC=C3)C(NC(CO)C(NC(CC(O)=O)C(NC(CCCNC(N)=N)C(NC(CC(C)C)C(NC(C(C)CC)C(NC(C(CC)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O
分子式C54H81N13O15
分子量1152.3
溶解度≥ 115.2mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Signal transducer and activator of transcription 6 fragment, (C54H81N13O15), a peptide with the sequence H2N-Ser-Tyr-Trp-Ser-Asp-Arg-Leu-Ile-Ile-OH, MW= 1152.3. STAT6 is a member of the STAT family of transcription factors[1]. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators[2]. This protein plays a central role in exerting IL4 mediated biological responses[3]. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.


References:
1. Leek JP, Hamlin PJ, BellSM, LenchNJ(1997). "Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization". Cytogenet. Cell Genet. 79 (3–4): 208–9.
2. Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges". Gene 285 (1–2): 1–24.
3. Shimoda K, van Deursen J, Sangster MY, et al. (1996). "Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene". Nature 380 (6575): 630–3.