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ALV2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ALV2图片
CAS NO:2438124-95-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
ALV2 是一种有效和选择性的 Helios 降解剂。ALV2 可以结合 CRBN,IC50 为 0.57 μM。Helios 是一种锌指转录因子,可以在炎症性肿瘤微环境中维持稳定的 Treg 细胞表型。
Cas No.2438124-95-7
分子式C26H26ClN5O5
分子量523.97
溶解度DMSO : 160 mg/mL (305.36 mM; Need ultrasonic)|Water :< 0.1 mg/mL (insoluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ALV2 is a potent and selective Helios degrader. ALV2 binds CRBN, with an IC50 of 0.57 μM. Helios is the zinc-finger transcription factor that can maintain a stable Treg cell phenotype in the inflammatory tumor microenvironment[1].

ALV2 (10 nM-100 μM) induces CRBN-Helios dimerization in the TR-FRET assay[1].ALV2 (0.1-10 μM) preferentially promotes Helios degradation in Jurkat cells[1].ALV2 (1 μM; pretreated for 18 h) promotes IL-2 secretion in Jurkat cells[1].

ALV2 (100 mg/kg; i.p. twice daily for 7 days) induces selective Helios degradation in vivo[1].

[1]. Wang ES, et, al. Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol. 2021 Jun;17(6):711-717.