您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > FABPs ligand 6
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
FABPs ligand 6
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
FABPs ligand 6图片
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
FABPs ligand 6 (MF6) 是一种 FABP5 和 FABP7 抑制剂，KD 值分别为 874 nM 和 20 nM。FABPs ligand 6 可用于多发性硬化症的研究。
别名MF6
分子式C28H27FN2O3
分子量458.52
溶解度DMSO : 250 mg/mL (545.23 mM; Need ultrasonic)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

FABPs ligand 6 (MF6) is an FABP5 and FABP7 inhibitor with KD values of 874 nM and 20 nM, respectively. FABPs ligand 6 can be used for multiple sclerosis research[1].

FABPs ligand 6 (MF6) rescues mitochondrial function by blocking voltagedependent anion channel (VDAC)-1-dependent mitochondrial macropore formation induced by psychosine in KG-1C cells, a FABP5- mediated injury[1].

MF 6 (1 mg/kg; i.g.; daily for 4 weeks) improves the severity of EAE (experimental autoimmune encephalomyelitis) and attenuates oxidative levels and the inflammatory response[1].

[1]. Cheng A, et al. A novel fatty acid-binding protein 5 and 7 inhibitor ameliorates oligodendrocyte injury in multiple sclerosis mouse models. EBioMedicine. 2021 Oct;72:103582.