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CCI-006
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CCI-006图片
CAS NO:292053-42-0
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议

产品介绍
CCI-006 是 MLL-重组白血病细胞的选择性抑制剂和化学增敏剂,通过抑制线粒体呼吸,导致 MLL-重组白血病细胞中不可克服的线粒体去极化和促凋亡的未折叠蛋白反应。
Cas No.292053-42-0
分子式C15H12N2O5S
分子量332.33
溶解度DMSO : ≥ 83.33 mg/mL (250.74 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells[1].

[1]. Somers K, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 Jan 22.