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Geldanamycin-FITC
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Geldanamycin-FITC图片
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
Geldanamycin-FITC 是一种格尔达霉素荧光探针，可用于 HSP90 抑制剂的荧光偏振分析。Geldanamycin-FITC 也可用于细胞表面 HSP90 的检测。
分子式C55H63N5O13S
分子量1034.18
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC also can be used for detection of cell surface HSP90[1][2][3].

The HSP90 inhibitor Geldanamycin, when conjugated with FITC (GA-FITC) is cell-membrane impermeable, binding only cell surface HSP90 and inhibiting its functions but having no effect on cytosolic HSP90[3].

[1]. Kim J, et al. Development of a fluorescence polarization assay for the molecular chaperone Hsp90. J Biomol Screen. 2004;9(5):375‐381.
[2]. Posfai D, et al. Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity. Antimicrob Agents Chemother. 2018;62(4):e01799-17. Published 2018 Mar 27.
[3]. Imai T, et al. Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc Natl Acad Sci U S A. 2011;108(39):16363‐16368.