| CAS NO: | 47491-38-3 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 47491-38-3 |
| 别名 | 氮卓斯汀杂质 |
| Canonical SMILES | O=C1C2=CC=CC=C2C(CC3=CC=C(Cl)C=C3)=NN1C4CCNCCC4 |
| 分子式 | C21H22ClN3O |
| 分子量 | 367.9 |
| 溶解度 | DMSO: soluble |
| 储存条件 | -20буC |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | N-desmethyl Azelastine is an active metabolite of the histamine H1receptor antagonist azelastine .1,2It is formed from azelastine primarily by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2D6 and, to a lesser extent, by CYP1A2.2N-desmethyl Azelastine (1 µM) inhibits acetylcholine-induced depolarization and contractions in isolated human tracheal smooth muscle.1It also inhibits transport of daunorubicin and digoxin in LLC-GA5-CoL150 cells overexpressing P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1; IC50s = 11.8 and 41.8 µM, respectively).3 1.Richards, I.S., Miller, L., Solomon, D., et al.Azelastine and desmethylazelastine suppress acetylcholine-induced contraction and depolarization in human airway smooth muscleEur. J. Pharmacol.186(2-3)331-334(1990) 2.Nakajima, M., Nakamura, S., Tokudome, S., et al.Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: Evaluation of approach to predict the contribution of multiple CYPsDrug Metab. Dispos.27(12)1381-1391(1999) 3.Katoh, M., Nakajima, M., Yamazaki, H., et al.Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transportEur. J. Pharm. Sci.12(4)505-513(2001) |
m.cnreagent.com