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N-desmethyl Trimipramine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N-desmethyl Trimipramine图片
CAS NO:2293-21-2
包装与价格：
包装价格(元)
500 µg电议
1mg电议
5mg电议

产品介绍
An active metabolite of trimipramine
Cas No.2293-21-2
别名N-去甲曲米帕明
Canonical SMILESCC(CNC)CN(C1=C(CC2)C=CC=C1)C3=C2C=CC=C3
分子式C19H24N2
分子量280.4
溶解度Chloroform: slightly soluble,Methanol: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-desmethyl Trimipramine is an active metabolite of the tricyclic antidepressant trimipramine .1It inhibits the norepinephrine transporter (NET), serotonin (5-HT) transporter (SERT), and dopamine transporter (DAT; IC50s = 2.92, 6.22, and 29.5 µM, respectively) as well as organic cation transporter 1 (OCT1) and OCT2 (IC50s = 3.19 and 10.4 µM, respectively) in HEK293 cells expressing the human transporters.

1.Haenisch, B., Hiemke, C., and BÖnisch, H.Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transportersPsychopharmacology (Berl)217(2)289-295(2011)