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Glycine-15N
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Glycine-15N图片
CAS NO:7299-33-4
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
Glycine-15N 是一种 15N 标记的 Glycine。Glycine 是中枢神经系统的一种抑制性神经递质,同时也是 glutamate 的一种联合激动剂,有促进谷氨酸能 NMDA (N-methyl-D-aspartic acid ) 受体兴奋的潜能。
Cas No.7299-33-4
别名甘氨酸 15N
分子式C2H515NO2
分子量76.06
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Glycine-15N is the 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Johnson JW, et al. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature. 1987 Feb 5-11;325(6104):529-31.