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Samatasvir
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Samatasvir图片
CAS NO:1312547-19-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Samatasvir (IDX71) 是一种有效的,具有口服活性的 NS5A HCV 复制抑制剂。Samatasvir 对感染性 HCV 和复制子有效且有选择性,在基因型 1至5 复制子中,EC50 在 2 至 24 pM 的范围内。
Cas No.1312547-19-5
别名IDX719; IDX18719
分子式C47H48N8O6S2
分子量885.06
溶解度DMSO : 50 mg/mL (56.49 mM; Need ultrasonic)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Samatasvir (IDX71) is a potent, orally active NS5A inhibitor of HCV replication. Samatasvir is effective and selective against infectious HCV and replicons, with EC50s falling within a tight range of 2 to 24 pM in genotype 1 through 5 replicons[1].

Samatasvir (IDX719) retains full activity in the presence of HIV and hepatitis B virus (HBV) antivirals and is not cross-resistant with HCV protease, nucleotide, and nonnucleoside polymerase inhibitor classes[1].

[1]. Bilello JP, et al. In vitro activity and resistance profile of samatasvir, a novel NS5A replication inhibitor of hepatitis C virus. Antimicrob Agents Chemother. 2014;58(8):4431-4442.