| CAS NO: | 6537-80-0 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Cas No. | 6537-80-0 |
| 别名 | 菊苣酸; Cichoric acid; Dicaffeoyltartaric acid |
| 分子式 | C22H18O12 |
| 分子量 | 474.37 |
| 溶解度 | Water : 100 mg/mL (210.81 mM; Need ultrasonic)|DMSO : 1 mg/mL (2.11 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects[1][2][3]. Chicoric acid (Cichoric acid; 10-200 μM; for 24, 48, and 72 h) causes a dose- and time-dependent decrease in cell viability[1]. Chicoric acid (100 μM; 48 h) induces apoptosis through caspase-3-dependent pathway[1]. Chicoric acid (100 μM; 48 h) decreases the protein level of p-Akt[1]. Chicoric acid (25, 50, 100 µM; for 24 hours) dramatically improves glucose uptake in a dose-dependent manner, and Chicoric acid further enhances insulin-induced (100 nM; 30 min) glucose uptake by 57.7% in HepG2 cells[2]. Chicoric acid (100 µM; for 24 hours) restores glucosamine-induced impairment of GLUT2 translocation through activating PI3K/Akt pathway in HepG2 cells[2]. Chicoric acid (100 µM) has no effects on HepG2 cell viability[2]. Chicoric acid (Cichoric acid; 60 mg/kg/day; drinking water for 4 weeks) inhibits pancreas apoptosis and adjusts islet function in diabetic mice, leading to an increase in insulin generation and secretion in C57BL/6J mice with Streptozotocin (STZ; 50 mg/kg; ip; for consecutive 5 days)[3]. [1]. Haifang Xiao, et al. Chicoric acid induces apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. J Agric Food Chem. 2013 Feb 20;61(7):1509-20. |
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