Carubicin hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

52794-97-5

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议

产品介绍

Carubicin hydrochloride 是一种微生物衍生的化合物。Carubicin hydrochloride 是 VHL 缺陷型 (VHL-/-) CCRCC 细胞增殖的有效抑制剂。Carubicin hydrochloride 还通过独立于 p53 或缺氧诱导因子 HIF2 的机制诱导细胞凋亡 (apoptosis)。Carubicin hydrochloride具有研究癌症疾病的潜力。

Cas No.	52794-97-5
别名	盐酸洋红霉素,Carminomycin hydrochloride; Carminomicin I hydrochloride
分子式	C26H28ClNO10
分子量	549.95
溶解度	DMSO : 62.5 mg/mL (113.65 mM; Need ultrasonic)
储存条件	4°C, away from moisture
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Carubicin hydrochloride is a microbially-derived compound. Carubicin hydrochloride is an effective inhibitor of VHL-defective (VHL-/-) CCRCC cell proliferation. Carubicin hydrochloride also induces apoptosis by a mechanism independent of p53 or hypoxia-inducible factor HIF2. Carubicin hydrochloride has the potential for the research of cancer diseases[1][2]. [1]. Woldemichael GM, et al. Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells. Cancer Res. 2011 Jan 1;71(1):134-42. [2]. Tevyashova AN, et al. Carminomycin, 14-hydroxycarminomycin and its novel carbohydrate derivatives potently kill human tumor cells and their multidrug resistant variants. J Antibiot (Tokyo). 2004 Feb;57(2):143-50.