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SACLAC
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SACLAC图片
CAS NO:2248703-42-4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An inhibitor of acid ceramidase
Cas No.2248703-42-4
Canonical SMILESClCC(N[C@@H](CO)[C@@H](CCCCCCCCCCCCCCC)O)=O
分子式C20H40ClNO3
分子量378
溶解度Chloroform: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SACLAC is an irreversible inhibitor of acid ceramidase (Ki= 97.1 nM) and a derivative of the acid ceramidase inhibitor SABRAC .1It decreases levels of sphingosine-1-phosphate (S1P) and increases total ceramide levels in OCI-AML-2 acute myeloid leukemia (AML) cells when used at a concentration of 2.5 µM.2SACLAC (10 and 20 µM) induces apoptosis in primary AML cells. It reduces leukemic burden in MV4-11 and U937 AML mouse xenograft models when administered at a dose of 5 mg/kg.

1.OrdÓÑez, Y.F., Abad, J.L., Aseeri, M., et al.Activity-based imaging of acid ceramidase in living cellsJ. Am. Chem. Soc.141(19)7736-7742(2019) 2.Pearson, J.M., Tan, S.-F., Sharma, A., et al.Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemiaMol. Cancer Res.18(3)352-363(2020)