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BM-1244
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BM-1244图片
CAS NO:1619923-32-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
BM-1244 是一种有效的 Bcl-xL/Bcl-2 抑制剂,对 Bcl-xL 和 Bcl-2 的Ki 分别为 134 和 450 nM。BM-1244 抑制衰老成纤维细胞 (SnCs),EC50 为 5 nM。
Cas No.1619923-32-8
别名APG-1252-M1
分子式C54H59ClF4N6O8S4
分子量1159.79
溶解度DMSO : 200 mg/mL (172.45 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM. (From patent WO2019033119A1)[1].

[1]. Jill Hopkins, et al. Treatment of ophthalmic conditions such as macular degeneration, glaucoma, and diabetic retinopathy using pharmaceutical agents that eliminate senescent cells. WO2019033119A1.
[2]. Kim R. Unknotting the roles of Bcl-2 and Bcl-xL in cell death. Biochem Biophys Res Commun. 2005;333(2):336-343.