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Fisetin-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fisetin-d5图片
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of fisetin
Canonical SMILESO=C1C2=C(C([2H])=C(O)C([2H])=C2)OC(C3=C([2H])C(O)=C(O)C([2H])=C3[2H])=C1O
分子式C15H5D5O6
分子量291.3
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 5 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Fisetin-d5is intended for use as an internal standard for the quantification of fisetin by GC- or LC-MS. Fisetin is a flavonoid that has been found in various fruits and vegetables and has diverse biological activities.1,2,3,4It scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay and inhibits oxidative burst induced by N-Formyl-Met-Leu-Phe in isolated human polymorphonuclear neutrophils (PMNs) when used at a concentration of 10 µM.1,3Fisetin (10-60 µM) induces cell cycle arrest at the G1phase and apoptosis in, as well as inhibits the proliferation of, LNCaP prostate cancer cells.2It inhibits LPS-induced production of nitrite, prostaglandin E2, and NF-κB activation in RAW 264.7 cells.3Fisetin (1 mg/animal) reduces tumor growth in a CWR22RΥ1 prostate cancer mouse xenograft model.4

1.Khan, N., Syed, D.N., Ahmad, N., et al.Fisetin: A dietary antioxidant for health promotionAntioxid. Redox Signal.19(2)151-162(2013) 2.Khan, N., Afaq, F., Syed, D.N., et al.Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cellsCarcinogenesis29(5)1049-1056(2008) 3.Wang, L., Tu, Y.-C., Lian, T.-W., et al.Distinctive antioxidant and antiinflammatory effects of flavonolsJ. Agric. Food Chem.54(26)9798-9804(2006) 4.Khan, N., Asim, M., Afaq, F., et al.A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude miceCancer Res.68(20)8555-8563(2008)