| CAS NO: | 82-57-5 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 500mg | 电议 |
| 1 g | 电议 |
| Cas No. | 82-57-5 |
| 别名 | 齿阿米素 |
| Canonical SMILES | O=C1C=C(C)OC2=C1C(OC)=C3C=COC3=C2 |
| 分子式 | C13H10O4 |
| 分子量 | 230.2 |
| 溶解度 | DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,DMSO: 5 mg/ml,Ethanol: 1 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Visnagin is a polyketide synthase-derived furanochromone originally isolated fromA. visnagathat has diverse biological activities.1,2,3,4,5It inhibits the germination and growth of ryegrass (IC50s = 502 and 214 µM, respectively).2Visnagin (100 µg/ml) is cytotoxic to, and induces apoptosis in, HT-144 melanoma cells.3It reduces LPS-stimulated increases in the secretion of TNF-α, IL-1β, and IFN-γ in BV-2 microglial cells when used at concentrations of 50 and 100 µM.4Visnagin (25 mg/kg) protects against cardiomyopathy induced by doxorubicin in mice.5 1.Abe, I.Engineering of plant polyketide biosynthesisChem. Pharm. Bull. (Tokyo)56(11)1505-1514(2008) 2.Travaini, M.L., Sosa, G.M., Ceccarelli, E.A., et al.Khellin and visnagin, furanochromones from Ammi visnaga (L.) Lam., as potential bioherbicidesJ. Agric. Food Chem.64(50)9475-9487(2016) 3.Aydo?mu?-ÖztÜrk, F., Jahan, H., Beyazit, N., et al.The anticancer activity of visnagin, isolated from Ammi visnaga L., against the human malignant melanoma cell lines, HT 144Mol. Biol. Rep.46(2)1709-1714(2019) 4.Lee, J.-K., Jung, J.-S., Park, S.-H., et al.Anti-inflammatory effect of visnagin in lipopolysaccharide-stimulated BV-2 microglial cellsArch. Pharm. Res.33(11)1843-1850(2010) 5.Liu, Y., Asnani, A., Zou, L., et al.Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenaseSci. Transl. Med.6(266)266ra170(2014) |
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