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DM4(hydrate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DM4(hydrate)图片
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
A derivative of maytansine
Canonical SMILESC[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCC(C)(S)C)=O)=O)=O)C)=C(Cl)C(OC)=C4)\C)OC)(NC(O3)=O)O)C)([H])O1.O
分子式C38H54ClN3O10S·XH2O
分子量780.4
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 20 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DM4 is a thiol-containing derivative of the tubulin polymerization inhibitor maytansine.1,2It is cytotoxic to SK-BR-3 cells (IC50= 3.3 nM).1DM4, conjugated to a humanized CD205-targeting monoclonal antibody, is selectively cytotoxic to a variety of CD205-expressing human cancer cells (EC50s = 0.1-1.32 nM) over non-CD205-expressing cells (EC50s = 14.2-22.66 nM) and reduces tumor growth in various mouse xenograft and patient-derived (PDX) cancer models.3

1.Widdison, W.C., Wilhelm, S.D., Cavanagh, E.E., et al.Semisynthetic maytansine analogues for the targeted treatment of cancerJ. Med Chem.49(14)4392-4408(2006) 2.Remillard, S., Rebhun, L.I., Howie, G.A., et al.Antimitotic activity of the potent tumor inhibitor maytansineScience189(4207)1002-1005(1975) 3.Merlino, G., Fiascarelli, A., Bigioni, M., et al.MEN1309/OBT076, a first-in-class antibody-drug conjugate targeting CD205 in solid tumorsMol. Cancer Ther.18(9)1533-1543(2019)