| CAS NO: | 756875-51-1 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 756875-51-1 |
| Canonical SMILES | O=C(C(CCCCCC)C(CCCCCCC)=O)NC(CO)CO |
| 分子式 | C19H37NO4 |
| 分子量 | 343.5 |
| 溶解度 | DMSO: 30 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | K6PC-5 is a sphingosine kinase 1 (SPHK1) activator.1,2,3It activates SPHK1 in F9-12 teratocarcinoma cell lysates and isolated murine blood in a concentration-dependent manner.1K6PC-5 (25 and 50 µM) induces calcium oscillations in HaCaT keratinocytes. It inhibits cell death induced by oxygen-glucose deprivation/reoxygenation in SH-SY5Y neuroblastoma cells when used at a concentration of 10 µM.2Topical administration of K6PC-5 (1%) increases stratum corneum integrity and corneodesmosome density in a mouse model of photoaging induced by long-term exposure to ultraviolet A (UVA) and UVB radiation.3 1.Hong, J.H., Youm, J.K., Kwon, M.J., et al.K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signalingJ. Invest. Dermatol.1282166-2178(2008) 2.Liu, H., Zhang, Z., Xu, M., et al.K6PC-5 activates SphK1-Nrf2 signaling to protect neuronal cells from oxygen glucose deprivation/re-oxygenationCell Physiol. Biochem.51(4)1908-1920(2018) 3.Park, H.-y., Youm, J.-K., Kwon, M.J., et al.K6PC-5, a novel sphingosine kinase activator, improves long-term ultraviolet light-exposed aged murine skinExp. Dermatol.17(1)829-836(2008) |
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