| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 别名 | JADA82 trihydrochloride; PCK82 trihydrochloride |
| 分子式 | C27H43Cl3N4O5 |
| 分子量 | 610.01 |
| 溶解度 | Methanol : 250 mg/mL (409.83 mM; Need ultrasonic)|DMSO : 50 mg/mL (81.97 mM; Need ultrasonic) |
| 储存条件 | 4°C, away from moisture |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | JQKD82 (JADA82) trihydrochloride is a cell-permeable and selective KDM5 inhibitor. JQKD82 trihydrochloride increases H3K4me3 and can be used for the research of multiple myeloma[1]. JQKD82 (0.3 μM; 24 hours) trihydrochloride causes an increase in the global H3K4me3 level of MM.1S cells[1].JQKD82 (0.1-10 μM; day 1-day 5) trihydrochloride inhibits the growth of MM.1S cells in a dose- and time-dependent manner. JQKD82 trihydrochloride is potent at eliciting growth suppression in MM.1S cells (IC50=0.42 μM)[1].JQKD82 (1 μM; 24 hours) trihydrochloride induces G1 cell-cycle arrest by 48 hours in MM.1S and MOLP-8 cells[1]. JQKD82 (50-75 mg/kg; i.p.; twice a day for 3 weeks) trihydrochloride has anti-multiple myeloma activity[1].JQKD82 trihydrochloride displays an increase in H3K4me3 levels and results in a dramatic reduction of MYC immuno-staining in vivo[1]. [1]. Jun Qi, et al. Histone demethylase 5 inhibitors and uses thereof. WO2020033377A1. |
m.cnreagent.com