SGC-SMARCA-BRDVIII

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SGC-SMARCA-BRDVIII

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1997319-84-2

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

SGC-SMARCA-BRDVIII 是一种有效和选择性的 SMARCA2/4 和 PB1(5) 抑制剂，Kd 值分别为 35 nM，36 nM 和 13 nM。SGC-SMARCA-BRDVIII 还抑制 PB1(2) 和 PB1(3)，Kd 值分别为 3.7 和 2.0 μM。SGC-SMARCA-BRDVIII 可以阻断 3T3-L1 鼠成纤维细胞的脂肪生成。

Cas No.	1997319-84-2
分子式	C19H25N5O3
分子量	371.43
溶解度	DMSO : 25 mg/mL (67.31 mM; ultrasonic and warming and heat to 60℃)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts[1][2]. SGC-SMARCA-BRDVIII (compound 22) (1 μM; 14 days) blocks adipocyte differentiation in 3T3-L1 murine fibroblasts[1]. [1]. Wanior M, et, al. Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J Med Chem. 2020 Dec 10;63(23):14680-14699. [2]. MÉlin L, et, al. Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2. ACS Omega. 2021 Aug 9;6(33):21327-21338.