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653-47 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
653-47 hydrochloride图片
CAS NO:1224567-46-7
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
653-47 hydrochloride 是一种增强剂,能显著增强 666-15 的 cAMP 反应元件结合蛋白 (CREB) 抑制活性。653-47 hydrochloride 也是一种很弱的抑制剂,其 IC50 为 26.3 μM。
Cas No.1224567-46-7
分子式C20H20Cl2N2O3
分子量407.29
溶解度DMSO : 250 mg/mL (613.81 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

653-47 hydrochloride, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].

653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15[1].

[1]. Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.