| CAS NO: | 135-23-9 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| Cas No. | 135-23-9 |
| 别名 | 盐酸美沙吡林,Thenylpyramine hydrochloride |
| Canonical SMILES | CN(C)CCN(CC1=CC=CS1)C2=NC=CC=C2.Cl |
| 分子式 | C14H19N3S•HCl |
| 分子量 | 297.8 |
| 溶解度 | DMF: 15 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Methapyrilene is a histamine H1receptor antagonist (Ki= 4.5 nM) and non-genotoxic carcinogen.1,2Dietary administration of methapyrilene (0.1%) induces liver tumors in rats, with greater than 50% of rats incurring distant metastases.3It decreases the acetylation of histone 3 lysine 9 (H3K9) and H3K56, as well as the di- and trimethylation of H3K4 and H4K20, respectively, in rat liver when administered at 40 mg/kg per day for six weeks.2Methapyrilene also increases 4-hydroxy nonenal (4-NHE) protein adducts in rat liver. Formulations containing methapyrilene were previously used as sleep aids. 1.Tran, V.T., Chang, R.S.L., and Snyder, S.H.Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramineProc. Natl. Acad. Sci. U.S.A.75(12)6290-6294(1978) 2.Shpyleva, S., Dreval, K., de Conti, A., et al.Editor's highlight: Organ-specific epigenetic changes induced by the nongenotoxic liver carcinogen methapyrilene in fischer 344 ratsToxicol. Sci.156(1)190-198(2017) 3.Lijinsky, W., Reuber, M.D., and Blackwell, B.N.Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochlorideScience209(4458)817-819(1980) |
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