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L-Phenylalanine-13C6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Phenylalanine-13C6图片
CAS NO:180268-82-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
L-Phenylalanine-13C6 ((S)-2-Amino-3-phenylpropionic acid-13C6) 是 13C 标记的 L-Phenylalanine。
Cas No.180268-82-0
别名L-苯丙氨酸-13C6,(S)-2-Amino-3-phenylpropionic acid-13C6
Canonical SMILESOC([C@@H](N)C[13C]1=[13CH][13CH]=[13CH][13CH]=[13CH]1)=O
分子式C3[13C]6H11NO2
分子量171.2
溶解度Water: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L-Phenylalanine-13C6is intended for use as an internal standard for the quantification of phenylalanine by GC- or LC-MS. L-Phenylalanine is an essential amino acid.1,2,3Blood and brain levels of L-phenylalanine are increased and associated with progressive cognitive impairments, seizures, motor deficits, and autism in patients with phenylketonuria, an inborn error of metabolism characterized by mutations in the gene encoding phenylalanine hydroxylase (PAH). L-Phenylalanine inhibits NMDA-induced currents in primary rat hippocampal neurons (IC50= 1.71 mM).1It also assembles into fibrilsin vitrothat are cytotoxic to PC12 and CHO cells when used at concentrations ranging from 1.16 to 15 mM.2

1.Glushakov, A.V., Dennis, D.M., Morey, T.E., et al.Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuriaMol. Psychiatry7(4)359-367(2002) 2.Adler-Abramovich, L., Vaks, L., Carny, O., et al.Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuriaNat. Chem. Biol.8(8)701-706(2012) 3.Blau, N., van Spronsen, F.J., and Levy, H.L.PhenylketonuriaLancet376(9750)1417-1427(2010)