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GPX4 Inhibitor 26a
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GPX4 Inhibitor 26a图片
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A GPX4 inhibitor
Canonical SMILESClCC(N(C(C1=CSC2=CC=CC=C21)C(NCCC3=CC=CC=C3)=O)C4=CC=C(C5=CN=CO5)C=C4)=O
分子式C29H24ClN3O3S
分子量530
溶解度Chloroform: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GPX4 inhibitor 26a is an inhibitor of glutathione peroxidase 4 (GPX4).1It inhibits GPX4 activity by 71.7% at 1 µM. GPX4 inhibitor 26a is cytotoxic to 4T1 and MCF-7 breast cancer cells and HT-1080 fibrosarcoma cells (IC50s = 0.78, 6.9, and 0.15 µM, respectively). It decreases intracellular glutathione (GSH) levels and induces lipid peroxidation and ferroptosis in 4T1 cells when used at a concentration of 5 µM. GPX4 inhibitor 26a (15 and 30 mg/kg) reduces tumor growth in a 4T1 mouse xenograft model.

1.Tiedt, R., Degenkolbe, E., Furet, P., et al.A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patientsCancer Res.71(15)5255-5264(2011)