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O-desethyl Dapagliflozin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
O-desethyl Dapagliflozin图片
CAS NO:864070-37-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
An SGLT2 inhibitor and active metabolite of dapagliflozin
Cas No.864070-37-1
别名达格列净杂质
Canonical SMILESO[C@H]([C@H]1O)[C@H](C(C=C2)=CC(CC(C=C3)=CC=C3O)=C2Cl)O[C@@H]([C@H]1O)CO
分子式C19H21ClO6
分子量380.8
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

O-desethyl Dapagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50= 9.4 nM) and active metabolite of dapagliflozin .1,2It is selective for SGLT2 over SGLT1 (IC50= 970 nM).1

1.Xu, B., Feng, Y., Cheng, H., et al.C-aryl glucosides substituted at the 4’-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetesBioorg. Med. Chem. Lett.21(15)4465-4470(2011) 2.Xu, G., Lv, B., Roberge, J.Y., et al.Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetesJ. Med. Chem.57(4)1236-1251(2014)