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Roxatidine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Roxatidine图片
CAS NO:78273-80-0
包装与价格:
包装价格(元)
500 µg电议
1mg电议
5mg电议
10mg电议

产品介绍
罗沙替丁是醋酸罗沙替丁盐酸盐的活性代谢物,是组胺 H2 受体拮抗剂。
Cas No.78273-80-0
别名罗沙替丁
Canonical SMILESO=C(CO)NCCCOC1=CC=CC(CN2CCCCC2)=C1
分子式C17H26N2O3
分子量306.4
溶解度DMSO: up to 25 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Roxatidine is a histamine H2receptor antagonist and major active metabolite of roxatidine acetate .1Roxatidine reduces histamine-induced adenylate cyclase production in guinea pig parietal cells (IC50= 0.8 µM). It inhibits histamine-induced hydrogen ion accumulation in the same cells (pA2= 7.03). Roxatidine (200 mg/kg) reduces small intestinal lesion area in a rat model of gastric mucosal injury induced by indomethacin .2

1.Sewing, K.-F., Beil, W., and Hannemann, H.Comparative pharmacology of histamine H2-receptor antagonistsDrugs35(Suppl. 3)25-29(1988) 2.Umegaki, E., Yoda, Y., Tokioka, S., et al.Protective effect of roxatidine against indomethacin induced small intestinal mucosal injury in ratsJ. Gastroenterol. Hepatol.25(Suppl. 1)S35-S40(2010)