Melittin(trifluoroacetate salt)

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Melittin(trifluoroacetate salt)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Melittin(trifluoroacetate salt)图片

包装与价格：

包装	价格(元)
500 µg	电议
1mg	电议
5mg	电议

产品介绍

The principal cytotoxic component of bee venom

Canonical SMILES	NC([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@H](CO)NC([C@@]([C@H](CC)C)([H])NC([C@H](CC(C)C)NC([C@@H](NC([C@@H]1CCCN1C([C@H](CC(C)C)NC(CNC([C@@]([C@@H](C)O)([H])NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@@H](NC(CNC([C@@]([C@H](CC)C)([H])NC(CN[H])=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式	C₁₃₁H₂₂₉N₃₉O₃₁• XCF₃COOH
分子量	2846.5
溶解度	DMF: 25 mg/ml,DMSO: 25 mg/ml,PBS (pH 7.2): 3 mg/ml
储存条件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Melittin is a small protein that is the principal cytotoxic component of venom of the honey bee,A. mellifera.¹Structurally, melittin consists of two α-helical segments forming a bent rod, with hydrophilic residues on the convex side and hydrophobic sites on the concave side.^1,2This allows melittin molecules to assemble as tetramers on membrane surfaces and form pores, resulting in cell death. Bee venom is also known to stimulate phospholipase A₂(PLA₂) activity, and this may be linked to melittin-mediated pore production as well as the presence of low molecular weight PLA₂enzymes in the venom.^2,3Melittin also has antimicrobial properties, which, combined with its cytolytic properties, extends its potential for therapeutic applications.³ 1.Terwilliger, T.C., and Eisenberg, D.The structure of melittin. II. Interpretation of the structureThe Journal of Biological Chemisty257(11)6016-6022(1982) 2.Kourie, J.I., and Shorthouse, A.A.Properties of cytotoxic peptide-formed ion channelsAmerican Journal of Physiology.Cell Physiology278C1063-C1087(2000) 3.Moreno, M., and Giralt, E.Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: Melittin, apamin and mastoparanToxins71126-1150(2015)