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Oleoyl-Coenzyme A(sodium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Oleoyl-Coenzyme A(sodium salt)图片
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An acyl-CoA thioester
Canonical SMILESO[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCCCCCC/C=C\CCCCCCCC)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP(O)(O)=O.[Na]
分子式C39H68N7O17P3S • Na
分子量1055
溶解度Water: 10mg/mL
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Oleoyl-coenzyme A (oleoyl-CoA) is a thioester of oleic acid and CoA . It is a substrate for several acyl-CoA-dependent enzymes, including acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1), ACAT-2, acyl-CoA dehydrogenase-9 (ACAD-9), membrane-bound O-acyltransferase 1 (MBOAT1), and MBOAT2.1,2,3Oleoyl-CoA binds the fatty acid metabolism regulator protein (FadR) promoter inE. coli(Ki= 0.005 µM).4Oleoyl-CoA (1 µM) activates sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 inXenopusoocytes.5

1.Seo, T., Oelkers, P.M., Giattina, M.R., et al.Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cellsBiochemistry40(15)4756-4762(2001) 2.Ensenauer, R., He, M., Willard, J.-M., et al.Human acyl-CoA dehydrogenase-9 plays a novel role in the mitochondrial β-oxidation of unsaturated fatty acidsJ. Biol. Chem.280(37)32309-32316(2005) 3.GijÓn, M.A., Riekhof, W.R., Zarini, S., et al.Lysophospholipid acyltransferases and arachidonate recycling in human neutrophilsJ. Biol. Chem.283(44)30235-30245(2008) 4.DiRusso, C.C., Heimert, T.L., and Metzger, A.K.Characterization of FadR, a global transcriptional regulator of fatty acid metabolism in Escherichia coli. Interaction with the fadB promoter is prevented by long chain fatty acyl coenzyme AJ. Biol. Chem.267(12)8685-8691(1992) 5.Gribble, F.M., Proks, P., Corkey, B.E., et al.Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoAJ. Biol. Chem.273(41)26383-26387(1998)