CAS NO: | 84709-25-1 |
包装: | 1mg |
市场价: | 1800元 |
Cas No. | 84709-25-1 |
别名 | 表加巴辛,D-Epigalbacin |
Canonical SMILES | C[C@H]1[C@@H](C)[C@@H](C2=CC=C(OCO3)C3=C2)O[C@@H]1C4=CC=C(OCO5)C5=C4 |
分子式 | C20H20O5 |
分子量 | 340.37 |
储存条件 | 4°C, protect from light |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | (-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively[1]. (-)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs[1].(-)-zuonin A inhibits JNK activation by MKK4 and MKK7 and it inhibits substrate phosphorylation[1]. [1]. Tamer S. Kaoud, et al. Manipulating JNK Signaling with (-)-zuonin A. ACS Chem Biol. 2012 Nov 16; 7(11): 1873-1883. |