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Enniatin B1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Enniatin B1图片
CAS NO:19914-20-6
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
Enniatin B1 是一种镰刀菌毒素。
Cas No.19914-20-6
别名恩镰孢菌素 B1
Canonical SMILESC[C@@H](CC)[C@]([H])(N(C)C([C@@H](C(C)C)OC([C@H](C(C)C)N(C)C1=O)=O)=O)C(O[C@H](C(C)C)C(N(C)[C@@H](C(C)C)C(O[C@@H]1C(C)C)=O)=O)=O
分子式C34H59N3O9
分子量653.9
溶解度DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes[1]. Enniatin B1 crosss the blood-brain barrier[2]. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation[3].

CCF-STTG1 cells are sensitive to Enniatin B1 (IC50=4.4 μM)[2].

References:
[1]. Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo). 1992 Oct;45(10):1626-32.
[2]. Krug I, et al. Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells. PLoS One. 2018 May 16;13(5):e0197406.
[3]. Watjen W, et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res. 2009 Apr;53(4):431-40.