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SJF&alpha
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SJF&alpha图片
CAS NO:2254609-27-1
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
SJFα是一种含13个原子连接桥的PROTAC。SJFα降解p38α,DC50为7.16nM,但降解p38δ效果较差(DC50=299nM),且在浓度高达2.5μM时也不会降解其他p38亚型(β和γ)。
Cas No.2254609-27-1
Canonical SMILESFC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCCCOCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=C8)C8=NC=C4)C=C3)=O)=O)C=C1
分子式C59H67F2N7O11S
分子量1120.27
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM[1].

[1]. Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10(1):131.