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AZD7624
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
AZD7624图片
CAS NO:1095004-78-6
包装与价格：
包装价格(元)
250mg电议
500mg电议

产品介绍
AZD7624是一种可吸入的p38抑制剂，具有高效的抗炎活性。
Cas No.1095004-78-6
Canonical SMILESO=C(NC1CC1)C2=CC(N3C(C(NC4(C5=CC=CC=C5OCCNC)CC4)=NC=C3)=O)=C(C)C(F)=C2
分子式C27H30FN5O3
分子量491.56
溶解度DMSO: 250 mg/mL (508.58 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624 inhibits LPS-induced TNFα in human mononuclear cells, in whole blood as well as in alveolar macrophages in vitro, with pIC50u of 8.4, 8.7, and 9.0[1].

[1]. Pehrson R, et al. AZD7624, an Inhaled p38 Inhibitor, Demonstrates Local Lung Inhibition of LPS-Induced TNFα with Minimal Systemic Exposure. J Pharmacol Exp Ther. 2018 Jun;365(3):567-572.