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XL092
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
XL092图片
CAS NO:2367004-54-2
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
XL092 是有效的 Axl，Mer 和 C-Met 激酶活性的抑制剂，IC50 分别均<10 nM。XL092 具有抗肿瘤活性，具有研究激酶依赖性疾病和病症的潜力。
Cas No.2367004-54-2
分子式C29H25FN4O5
分子量528.53
溶解度DMSO : 25 mg/mL (47.30 mM; Need ultrasonic)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

XL092 is a potent inhibitor of the activity of Axl, Mer and C-Met kinase with IC50s of<10 nM, respectively. XL092 exhibits anti-tumor activity and has the potential for kinase-dependent diseases and conditions research[1].

XL092 (compound 8; 3 mg/kg; iv) has a T1/2 of 5.4 hours, a CL of 43 mL/hr•kg. XL092 (3 mg/kg; po) has a T1/2 of 7.1 hours and a Cmax of 11.4 μM for rats[1].

[1]. Lynne Canne Bannen, et al. Compounds for the treatment of kinase-dependent disorders. WO2019148044A1.