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IRAK4-IN-6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IRAK4-IN-6图片
CAS NO:2454244-02-9
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
IRAK4-IN-6 是一种口服高效、选择性 IRAK 抑制剂,IC50 为 4 nM,靶向 MyD88 L265P 突变型弥漫性大 B 细胞淋巴瘤。
Cas No.2454244-02-9
Canonical SMILESO=C(N1CCN([C@@H]2CC[C@@H](NC3=C4C(C=CC(CC#N)=N4)=NC(NC5=CN(C)N=C5)=N3)CC2)CC1)OC
分子式C25H32N10O2
分子量504.59
溶解度DMSO : 125 mg/mL (247.73 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IRAK4-IN-6 is an orally efficacious and selective IRAK4 inhibitor with an IC50 of 4 nM, and targetes MyD88 L265P mutant diffuse large B cell lymphoma[1].

References:
[1]. Degorce SL, et al. Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors TargetingMyD88L265P Mutant Diffuse Large B Cell Lymphoma. J Med Chem. 2019 Nov 1.