CAS NO: | 2383117-96-0 |
包装 | 价格(元) |
500µg | 电议 |
1mg | 电议 |
5mg | 电议 |
Cas No. | 2383117-96-0 |
Canonical SMILES | O=C([C@H]1N(C#N)CCC1)N2C3=CC=CC(C(C4=C5)=CNC4=NC=C5C#C)=C3CC2 |
分子式 | C23H19N5O |
分子量 | 381.4 |
溶解度 | Chloroform: 10 mg/ml,Ethanol: 5 mg/ml |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | IMP-1710 is an inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1; IC50= 38 nM in a fluorescence polarization assay) that contains an alkyne moiety for use in click chemistry reactions.1It is selective for UCH-L1 over a panel of 20 deubiquitinating enzymes at 1 µM. IMP-1710 inhibits TGF-β1-induced fibroblast-to-myofibroblast transition (FMT) in primary lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis (IC50= 740 nM). It has been used for labeling UCH-L1 in cell-based assays, followed by click reactions with azide-modified TAMRA and biotin capture reagents. 1.Panyain, N., Godinat, A., Lanyon-Hogg, T., et al.Discovery of a potent and selective covalent inhibitor and activity-based probe for the deubiquitylating enzyme UCHL1, with antifibrotic activityJ. Am. Chem. Soc.142(28)12020-12026(2020) |