| CAS NO: | 2068806-31-3 |
| 包装: | 10mg |
| 市场价: | 3366元 |
| Cas No. | 2068806-31-3 |
| Canonical SMILES | CN1C=C(NC2=NC=CC(=N2)N(C(=O)OCC2=CC=C(F)C=C2)C2=CC(NC(=O)C=C)=CC=C2)C=N1 |
| 分子式 | C25H22FN7O3 |
| 分子量 | 487.5 |
| 溶解度 | DMSO|24.37|50| |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Highly potent epidermal growth factor receptor (EGFR) and ErbB2 (human epidermal growth factor receptor; HER2) inhibitor. Inhibits wild type and tumorgenic mutated receptors (exon 20 insertion; Ex20Ins). Antiproliferative in vitro (IC50 values are 7.6, 30 - 95, 3.8 and 19 - 31 nM for Ba/F3 cells expressing wild type EGFR, EGFR with Ex20Ins mutation, wild type HER2 and HER2 with Ex20Ins mutation, respectively). Also inhibits other common EGFR mutants. Antiproliferative in patient-derived lung cancer cell lines. |
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