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SB-431542(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SB-431542(hydrate)图片
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Inhibitor of receptors ALK4, ALK5, and ALK7
Canonical SMILESNC(C(C=C1)=CC=C1C2=NC(C3=CC=C(OCO4)C4=C3)=C(C5=CC=CC=N5)N2)=O.O
分子式C22H16N4O3.XH2O
分子量384.4
溶解度DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 2 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SB-431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50= 94 nM)1. It is a less potent antagonist of ALK4 (IC50= 140 nM)2and ALK7.3It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested.3SB-431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer.3Through its effects on ALK/Smad signaling, SB-431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.4,5

1.Callahan, J.F., Burgess, J.L., Fornwald, J.A., et al.Identification of novel inhibitors of the transforming growth factor ß1 (TGF-ß1) type 1 receptor (ALK5)Journal of Medicinal Chemistry45(5)999-1001(2002) 2.Laping, N.J., Grygielko, E., Mathur, A., et al.Inhibition of Transforming Growth Factor (TGF)-ß1-Induced Extracellular Matrix with a Novel Inhibitor of the TGF-ß Type I Receptor Kinase Activity: SB-431542Molecular Pharmacology62(1)58-64(2002) 3.Inman, G.J., NicolÁs, F.J., Callahan, J.F., et al.SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7Molecular Pharmacology62(1)65-74(2002) 4.James, D., Levine, A.J., Besser, D., et al.TGFß/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cellsDevelopment1321273-1282(2005) 5.Chambers, S.M., Fasano, C.A., Papapetrou, E.P., et al.Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signalingNature Biotechnology27(3)275-280(2009)