| CAS NO: | 1847461-43-1 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 500mg | 电议 |
| Cas No. | 1847461-43-1 |
| 别名 | 莫博替尼; TAK-788; AP32788 |
| Canonical SMILES | O=C(C1=C(C2=CN(C)C3=C2C=CC=C3)N=C(NC4=C(OC)C=C(N(CCN(C)C)C)C(NC(C=C)=O)=C4)N=C1)OC(C)C |
| 分子式 | C32H39N7O4 |
| 分子量 | 585.7 |
| 溶解度 | DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:8): 0.11 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Mobocertinib is an inhibitor of mutant EGFR and HER2 receptors.1,2It is selective for the HER2 exon 20 mutants HER2V659E, HER2G660D, HER2G309E, and HER2S310Fover wild-type EGFR in Ba/F3 cells.1 1.Chouitar, J., Vincent, S., Brake, R., et al.TAK-788 is a novel and potent tyrosine kinase inhibitor with selective activity against EGFR/HER2AbstractsS811P2(13-32)(2018) 2.Neal, J., Doebele, R., Riely, G., et al.Safety, PK, and preliminary antitumor activity of the oral EGFR/HER2 exon 20 inhibitor TAK-788 in NSCLCAbstractsS599P1(13-44)(2018) |
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