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ML-209
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML-209图片
CAS NO:1334526-14-5
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议

产品介绍
ML-209 (compound 4n) 是一种二苯基丙酰胺,是一种视黄酸相关的孤儿受体 RORγ 拮抗剂,IC50 为 1.1 μM。
Cas No.1334526-14-5
Canonical SMILESC[C@@H]1C[C@H](C)CN(C(CC(C2=CC(OCO3)=C3C=C2)C4=C(O)C=C(OC)C=C4OC)=O)C1
分子式C25H31NO6
分子量441.5
溶解度DMSO: 100 mM
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 µM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM). ML-209 inhibits RORγt-dependent differentiation of isolated naÏve cord blood human CD4+T cells into Th17 T helper cells.

1.Huh, J.R., Englund, E.E., Wang, H., et al.Identification of potent and selective diphenylpropanamide RORγ inhibitorsACS Med. Chem. Lett.4(1)79-84(2013)