CAS NO: | 1334526-14-5 |
包装 | 价格(元) |
500 μg | 电议 |
1mg | 电议 |
5mg | 电议 |
Cas No. | 1334526-14-5 |
Canonical SMILES | C[C@@H]1C[C@H](C)CN(C(CC(C2=CC(OCO3)=C3C=C2)C4=C(O)C=C(OC)C=C4OC)=O)C1 |
分子式 | C25H31NO6 |
分子量 | 441.5 |
溶解度 | DMSO: 100 mM |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 µM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM). ML-209 inhibits RORγt-dependent differentiation of isolated naÏve cord blood human CD4+T cells into Th17 T helper cells. 1.Huh, J.R., Englund, E.E., Wang, H., et al.Identification of potent and selective diphenylpropanamide RORγ inhibitorsACS Med. Chem. Lett.4(1)79-84(2013) |