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Lipoxygenin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lipoxygenin图片
CAS NO:2247911-68-6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An inhibitor of 5-LO
Cas No.2247911-68-6
Canonical SMILESOC(C1=C(OC)C(C2=CC=CN=C2OC)=CN=C1OC)C3=CC=C(C=CC=C4)C4=C3
分子式C24H22N2O4
分子量402.4
溶解度DMF: 30mg/mL,DMSO: 30mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50value of 5 µM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 µM, respectively, in luciferase reporter assays). Lipoxygenin (5 and 10 µM) increases levels of troponin T (TnnT), a marker of cardiomyocyte differentiation, in human induced pluripotent stem cells (iPSCs) stimulated with BMP4 and the glycogen synthase kinase 3 (GSK3) inhibitor CHIR99021 .

1.Brand, S., Roy, S., SchrÖder, P., et al.Combined proteomic and in silico target identification reveal a role for 5-lipoxygenase in developmental signaling pathwaysCell Chem. Biol.25(9)1095-1106(2018)