CDK9-IN-13 (化合物 38) 是一种有效和选择性的 CDK 抑制剂，IC50 值<3 nM。CDK9-IN-13 在啮齿动物中的半衰期很短。
CDK9 <3nM(IC50) | CDK1 0.14μM(IC50) |
CDK2 0.72μM(IC50) | CDK7 0.40μM(IC50) |
| 产品描述 | CDK9-IN-13 (compound 38) is potent and selective CDK9 inhibitor, with an IC50 of<3 nM. CDK9-IN-13 exhibits short half-lives in rodents[1]. [1]. Barlaam B, et, al. Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement. J Med Chem. 2021 Oct 28;64(20):15189-15213. |
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