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ML372
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML372图片
CAS NO:1331745-61-9
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
ML372可抑制生存运动神经元 (SMN) 蛋白泛素化,增加 SMN 蛋白稳定性而不影响 mRNA 表达。ML372 可改善小鼠脊髓性肌萎缩症 (SMA)。ML372 具有脑渗透性,在体内具有合理的暴露量和半衰期。
Cas No.1331745-61-9
分子式C18H20N2O4S
分子量360.43
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo[1].

[1]. Mahlet B Abera, et al. ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice. JCI Insight. 2016 Nov 17;1(19):e88427.