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Tumulosic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tumulosic Acid图片
CAS NO:508-24-7
包装与价格:
包装价格(元)
500 µg电议
1mg电议
5mg电议

产品介绍
Tumulosic Acid 是一种三萜类化合物,可抑制 KLK5 蛋白酶活性 (IC50= 14.84 μM)。
Cas No.508-24-7
别名土莫酸
Canonical SMILESC[C@]12[C@@]([C@]([C@@H](CCC(C(C)C)=C)C(O)=O)([H])[C@@H](C1)O)(CCC3=C2CC[C@]4([H])[C@@]3(CC[C@@H](C4(C)C)O)C)C
分子式C31H50O4
分子量486.7
溶解度DMSO: 10 mM
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tumulosic acid is a triterpene that has been found inPoria cocosand has diverse biological activities.1,2,3,4It inhibits DNA topoisomerase I and II by 83.3 and 75.5%, respectively, when used at a concentration of 100 µM.1Tumulosic acid also inhibits kallikrein 5 and trypsin but not kallikrein 7 or chymotrypsin C (IC50s = 14.8, 45.3, >100, and >100 µM for the human enzymes, respectively).2It inhibits LPS-induced nitric oxide (NO) production (IC50= 42.5 µM) and activator protein 1 (AP-1) transcriptional activity in RAW 264.7 macrophages.3Tumulosic acid (30 µg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate in mice.4

1.Gao, L., Xu, M.-L., Lee, C.-S., et al.Cytotoxicity and DNA topoisomerases inhibitory activity of constituents from the sclerotium of Poria cocosArch. Pharm. Res.27(8)829-833(2004) 2.Matsubara, Y., Matsumoto, T., Koseki, J., et al.Inhibition of human kallikrein 5 protease by triterpenoids from natural sourcesMolecules22(11)1829(2017) 3.Cai, T.-G., and Cai, Y.Triterpenes from the fungus Poria cocos and their inhibitory activity on nitric oxide production in mouse macrophages via blockade of activating protein-1 pathwayChem. Biodivers.8(11)2135-2143(2011) 4.Nukaya, H., Yamashiro, H., Fukazawa, H., et al.Isolation of inhibitors of TPA-induce mouse ear edema from Hoelen Poria cocosChem. Pharm. Bull. (Tokyo)44(4)847-849(1996)