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IRE1α kinase-IN-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IRE1α kinase-IN-2图片
CAS NO:1414938-21-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
IRE1α kinase-IN-2 是一种有效的 IRE1α 激酶抑制剂,EC50 为 0.82 μM。IRE1α kinase-IN-2 抑制 IRE1α 激酶自磷酸化 (IC50=3.12 μM)。IRE1α kinase-IN-2 抑制 WT 细胞系 XBP1 mRNA 剪接。
Cas No.1414938-21-8
分子式C27H23F3N6O
分子量504.51
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC50 of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC50=3.12 μM). IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines[1].

IRE1α kinase-IN-2 (compound 3) inhibits XBP1 mRNA splicing, even during ER stress[1].

[1]. Wang L, Perera BG, Hari SB, et al. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012;8(12):982-989.