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Thymidine-d4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Thymidine-d4图片
CAS NO:347841-67-2
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of thymidine
Cas No.347841-67-2
别名胸苷-ALPHA,ALPHA,ALPHA,6-D4,DThyd-d4; NSC 21548-d4
Canonical SMILESOC[C@H]1O[C@](N2C(NC(C(C([2H])([2H])[2H])=C2[2H])=O)=O)([H])C[C@@H]1O
分子式C10H10D4N2O5
分子量246.3
溶解度DMF: 16 mg/mL,DMSO: 10mg/mL,PBS (pH 7.2): 5mg/mL
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Thymidine-d4is intended for use as an internal standard for the quantification of thymidine by GC- or LC-MS. Thymidine is a pyrimidine nucleoside composed of a deoxyribose sugar and thymine base.1It is phosphorylated by thymidine kinase 2 (TK2) in mitochondria to form deoxythymidine monophosphate .2Oral administration of thymidine in combination with deoxycytidine increases lifespan in aTk2 H126Nknock-in mouse model of TK2 deficiency.

1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Biochemistry(2002) 2.Lopez-Gomez, C., Levy, R.J., Sanchez-Quintero, M.J., et al.Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiencyAnn. Neurol.81(5)641-652(2017)