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AS-0141
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
AS-0141图片
CAS NO:1402057-88-8
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
AS-0141 (Cdc7-IN-6) 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM)，具有抗肿瘤活性，详情请参考文献 WO2019165473A1，compound I-D。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶，在细胞周期中对 DNA 复制的启动至关重要。
Cas No.1402057-88-8
别名Cdc7-IN-6
分子式C21H22F3N5O4
分子量465.43
溶解度DMSO : 83.33 mg/mL (179.04 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AS-0141 (Cdc7-IN-6) is a potent Cdc7 kinase inhibitor (IC50=4 nM), extracted from patent WO2019165473A1, compound I- D, has anti-tumor activity[1][2].

AS-0141 (Cdc7-IN-6) demonstrates potent inhibitory activity (IC50<3 µμ) in a range of solid tumor cell lines, including those of bladder (5673, RT1 12/84), sarcoma (143B, CADO-ES1, RD-ES, A673), colon and cecum (Colo-205, DLD-l, LS1034, SK-CO-l, SNU-C1), renal (U0.31), head-and-neck (CNE-2Z, RPMI-2650), melanoma (A2058, A875), and gastric (HGC-27) lineages[1].

[1]. Christian Andrew HASSIG, et al. Methods of treatment of cancer comprising cdc7 inhibitors. WO2019165473A1.