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PS47
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PS47图片
CAS NO:1180676-33-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
PS47 是 PS48 的非活性 E-异构体。PS48 是 PDK1 的激活剂。PS47 可用作 PS48 的阴性对照。
Cas No.1180676-33-8
分子式C17H15ClO2
分子量286.75
溶解度DMSO : 100 mg/mL (348.74 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PS47 is an inactive E-isomer of PS48. PS48 is an activator of PDK1. PS47 can be used as a negative control for PS48[1][2].

PS47 shows very low binding affinity or no binding to PDK1 (Kd>200 µM)[1].

[1]. Hindie V, et, al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol. 2009 Oct;5(10):758-64.
[2]. Pastor-Flores D, et, al. PIF-pocket as a target for C. albicans Pkh selective inhibitors. ACS Chem Biol. 2013 Oct 18;8(10):2283-92.