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AKT-IN-6
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
AKT-IN-6图片
CAS NO:1430056-54-4
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
AKT-IN-6 (Example 13) 是一种有效的 AKT 抑制剂。AKT-IN-6抑制 Akt1、Akt2 和 Akt3， IC50s 分别< 500nM，来自专利WO201305615A1。
Cas No.1430056-54-4
分子式C22H20FN5O
分子量389.43
溶解度DMSO : 125 mg/mL (320.98 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s< 500nM, respectively. (patent WO2013056015A1).

Akt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer[2].

[1]. Taisheng Huang; et al.Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors. WO2013056015A1.
[2]. Manning BD, et al. AKT/PKB signaling: navigating downstream. Cell. 2007;129(7):1261-1274.